Hereditary Cancer
Comprehensive evaluation for individuals and families at risk of hereditary cancers. Approximately 8–10% of cancers are caused by inherited gene mutations.
Understanding Hereditary Cancer
The Hereditary Cancer Clinic focuses on identifying individuals and families at increased risk of cancer due to inherited genetic factors.
Approximately 8–10% of cancers are hereditary, caused by gene mutations passed through families. In regions with high consanguinity, understanding these patterns is vital for prevention.
We evaluate syndromes including Hereditary Breast & Ovarian Cancer (HBOC), Lynch Syndrome, Li-Fraumeni Syndrome, Familial Adenomatous Polyposis (FAP), Retinoblastoma, and Pediatric hereditary cancers.
Our approach integrates early detection, tailored prevention strategies, and precision oncology to reduce the overall cancer burden for families.
Common Symptoms
- Cancer diagnosis at a young age (<50 years)
- Multiple cancers occurring in the same individual
- Strong family history of cancer (2 or more relatives)
- Occurrence of rare cancers (e.g., adrenocortical carcinoma, male breast cancer)
- Known presence of a familial genetic mutation
- Bilateral or multiple primary tumors
Risk Factors
- First-degree relative with a known hereditary cancer syndrome
- Strong family pedigree suggesting inherited susceptibility
- Belonging to a population with known founder mutations
- Previous cancer diagnosis with features suggesting a hereditary link
- History of pediatric or rare cancers in the family
Our Treatment Approach
Multidisciplinary, evidence-based treatment tailored to each patient.
1. Risk Assessment
Detailed personal and family history and pedigree (family tree) analysis to identify high-risk individuals.
2. Genetic Counseling
Pre-test counseling covering benefits, limitations, implications, and psychosocial support for informed decision-making.
3. Genetic Testing
Performed by Cancer Biology and Molecular Diagnostics department, including Targeted, Multigene panel testing, and Whole exome sequencing.
4. Personalized Risk Management
Tailored surveillance measures for cancer screening and risk-reducing strategies (medical/surgical).
5. Family-Based Care
Cascade testing for relatives and preventive strategies for multi-generational cancer risk reduction.
Related Departments
Our Hereditary Cancer Specialists
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